Plasma Thermogram Parameters Differentiate Status and Overall Survival of Melanoma Patients

Melanoma is the fifth most common cancer in United States and deadliest of all skin cancers. Even with recent advancements treatment, there still a 13% two-year recurrence rate, approximately 30% recurrences being distant metastases. Identifying patients at high risk for or advanced disease critical optimal clinical decision-making. Currently, substantial variability selection screening tests imaging, modalities characterized by relatively low accuracy. In current study, we built upon preliminary examination differential scanning calorimetry (DSC) melanoma setting to examine its utility diagnostic prognostic assessment. Using regression analysis, found that selected DSC profile (thermogram) parameters were useful differentiation between healthy controls, more complex models distinguishing no evidence from active disease. Thermogram features contributing third principal component (PC3) controls patients, Cox proportional hazards analysis indicated PC3 was predicting overall survival patients. With further development optimization classification method, could complement strategies improve screening, diagnosis, prognosis